Brain Degenerative Diseases P01-01 Control of Neurite Growth by S-nitroglutathione Reductase via Denitrosylation of Hdac2
نویسندگان
چکیده
Neurite growth control is central to the development and plasticity of neural circuits. By controlling intracellular level of S-nitrosoglutathione (GSNO), S-nitrosoglutathione reductase (GSNOR) has been implicated in many biological processes. However, as the sole brain alcohol dehydrogenase, its role in the nerve system is still largely a mystery. Here we report that GSNOR is significantly downregulated during developing mouse brain and the neurite growth was negatively regulated by GSNOR. Our data further show this negative regulation is mediated by denitrosylation of histone deacetylase 2 (HDAC2). Our findings define a novel role of GSNOR in neurite development via interacting with the NO signaling and provide a new molecular insight into the control of neurite growth and neurogenesis.
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